Total tooth loss and systemic correlates of inflammation: role of obesity.
Identifieur interne : 002F14 ( Main/Exploration ); précédent : 002F13; suivant : 002F15Total tooth loss and systemic correlates of inflammation: role of obesity.
Auteurs : Peter Meisel [Allemagne] ; Peter Wilke ; Reiner Biffar ; Birte Holtfreter ; Henry Wallaschofski ; Thomas KocherSource :
- Obesity (Silver Spring, Md.) [ 1930-739X ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Allemagne (épidémiologie), Bouche édentée (épidémiologie), Bouche édentée (étiologie), Facteurs de risque, Femelle, Humains, Indice de masse corporelle, Inflammation (), Inflammation (sang), Inflammation (épidémiologie), Jeune adulte, Marqueurs biologiques (sang), Mâle, Médiateurs de l'inflammation (métabolisme), Obésité (), Obésité (épidémiologie), Obésité (étiologie), Perte dentaire (épidémiologie), Perte dentaire (étiologie), Protéine C-réactive (métabolisme), Rapport taille-hanches, Sujet âgé, Sujet âgé de 80 ans ou plus, Études transversales.
- MESH :
- métabolisme : Médiateurs de l'inflammation, Protéine C-réactive.
- sang : Inflammation, Marqueurs biologiques.
- épidémiologie : Allemagne, Bouche édentée, Inflammation, Obésité, Perte dentaire.
- étiologie : Bouche édentée, Obésité, Perte dentaire.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Indice de masse corporelle, Inflammation, Jeune adulte, Mâle, Obésité, Rapport taille-hanches, Sujet âgé, Sujet âgé de 80 ans ou plus, Études transversales.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Biomarkers (blood), Body Mass Index, C-Reactive Protein (metabolism), Cross-Sectional Studies, Female, Germany (epidemiology), Humans, Inflammation (blood), Inflammation (complications), Inflammation (epidemiology), Inflammation Mediators (metabolism), Male, Middle Aged, Mouth, Edentulous (epidemiology), Mouth, Edentulous (etiology), Obesity (complications), Obesity (epidemiology), Obesity (etiology), Risk Factors, Tooth Loss (epidemiology), Tooth Loss (etiology), Waist-Hip Ratio, Young Adult.
- MESH :
- chemical , blood : Biomarkers.
- chemical , metabolism : C-Reactive Protein, Inflammation Mediators.
- geographic , epidemiology : Germany.
- blood : Inflammation.
- complications : Inflammation, Obesity.
- epidemiology : Inflammation, Mouth, Edentulous, Obesity, Tooth Loss.
- etiology : Mouth, Edentulous, Obesity, Tooth Loss.
- Adult, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Risk Factors, Waist-Hip Ratio, Young Adult.
Abstract
Obesity and edentulism are both associated with multiple systemic disorders with an inflammatory background including periodontal diseases. This study aimed to evaluate the different impact of obesity on inflammation in dentate and toothless subjects. The data came from the population-based, cross-sectional study SHIP (Study of Health in Pomerania). We determined anthropometric measures including BMI, waist-to-hip ratio (WHR), diagnostic periodontal parameters, and systemic metabolites. It was shown that measures of systemic markers of inflammation and lipid or glucose metabolism (P < 0.001) were increased with higher WHR. When adjusted for age, sex, smoking, diabetes, education, physical activity, and last dentist's appointment, C-reactive protein (CRP), fibrinogen, and leukocyte count were significantly related to WHR increasing from the first to the fourth WHR quartile (P < 0.001) as well as to the BMI. In both dentate and edentulous subjects higher WHR contributes significantly to increasing systemic CRP and fibrinogen with sex differences. In toothless subjects, while still dependent on increasing WHR, the inflammatory markers CRP and fibrinogen were higher than in dentate subjects, thereby revealing effect modification between sex and edentulism (P < 0.010). In conclusion, subjects with total tooth loss, although devoid of periodontal inflammation, may exhibit increased levels of systemic inflammatory mediators. Possible implications are discussed with respect to obesity and its relationship to inflammation.
DOI: 10.1038/oby.2011.218
PubMed: 21760638
Affiliations:
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Le document en format XML
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xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Indice de masse corporelle</term><term>Inflammation</term><term>Jeune adulte</term><term>Mâle</term><term>Obésité</term><term>Rapport taille-hanches</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Obesity and edentulism are both associated with multiple systemic disorders with an inflammatory background including periodontal diseases. This study aimed to evaluate the different impact of obesity on inflammation in dentate and toothless subjects. The data came from the population-based, cross-sectional study SHIP (Study of Health in Pomerania). We determined anthropometric measures including BMI, waist-to-hip ratio (WHR), diagnostic periodontal parameters, and systemic metabolites. It was shown that measures of systemic markers of inflammation and lipid or glucose metabolism (P < 0.001) were increased with higher WHR. When adjusted for age, sex, smoking, diabetes, education, physical activity, and last dentist's appointment, C-reactive protein (CRP), fibrinogen, and leukocyte count were significantly related to WHR increasing from the first to the fourth WHR quartile (P < 0.001) as well as to the BMI. In both dentate and edentulous subjects higher WHR contributes significantly to increasing systemic CRP and fibrinogen with sex differences. In toothless subjects, while still dependent on increasing WHR, the inflammatory markers CRP and fibrinogen were higher than in dentate subjects, thereby revealing effect modification between sex and edentulism (P < 0.010). In conclusion, subjects with total tooth loss, although devoid of periodontal inflammation, may exhibit increased levels of systemic inflammatory mediators. Possible implications are discussed with respect to obesity and its relationship to inflammation.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><name sortKey="Holtfreter, Birte" sort="Holtfreter, Birte" uniqKey="Holtfreter B" first="Birte" last="Holtfreter">Birte Holtfreter</name><name sortKey="Kocher, Thomas" sort="Kocher, Thomas" uniqKey="Kocher T" first="Thomas" last="Kocher">Thomas Kocher</name><name sortKey="Wallaschofski, Henry" sort="Wallaschofski, Henry" uniqKey="Wallaschofski H" first="Henry" last="Wallaschofski">Henry Wallaschofski</name><name sortKey="Wilke, Peter" sort="Wilke, Peter" uniqKey="Wilke P" first="Peter" last="Wilke">Peter Wilke</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Meisel, Peter" sort="Meisel, Peter" uniqKey="Meisel P" first="Peter" last="Meisel">Peter Meisel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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